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. 2012:849:347-59.
doi: 10.1007/978-1-61779-551-0_23.

Cell-to-cell transmission of α-synuclein aggregates

Seung-Jae Lee  1 , Paula Desplats, He-Jin Lee, Brian Spencer, Eliezer Masliah
Affiliations

Cell-to-cell transmission of α-synuclein aggregates

Seung-Jae Lee et al. Methods Mol Biol. 2012.

Abstract

It is now recognized that the cell-to-cell transmission of misfolded proteins such as α-synuclein contributes to the neurodegenerative phenotype in neurological disorders such as idiopathic Parkinson's disease, Dementia with Lewy bodies, and Parkinson's disease dementia. Thus, establishing cell-based models for the transmission of α-synuclein is of importance to understand the mechanisms of neurodegeneration in these disorders and to develop new therapies. Here we describe methods to study the neuron-to-neuron propagation of α-synuclein in an in vitro setting that also has in vivo applications.

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