Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May;15(2):247-50.
doi: 10.4103/0973-029X.84516.

Heterogenecity of fibroblasts

Manyam Ravikanth  1 , P Soujanya, K Manjunath, T R Saraswathi, C R Ramachandran
Affiliations

Heterogenecity of fibroblasts

Manyam Ravikanth et al. J Oral Maxillofac Pathol. 2011 May.

Abstract

Fibroblasts are a major stromal cell type present in human connective tissue maintaining the structural integrity in health. Depending on the situation, location and various conditions, fibroblasts exhibit considerable variation in morphology, size and shape that suggest the existence of discrete cellular subsets. The purpose of this short communication is to provide information regarding the heterogenecity of fibroblasts and its variability in physiological and pathological conditions.

Keywords: Fibroblasts; fibrocytes; giant cell fibroblasts; myofibroblasts.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Active fibroblasts, 20×
Figure 2
Figure 2
Vimentin positive, 20×
Figure 3
Figure 3
Inactive fibroblasts, 20×
Figure 4
Figure 4
Fibrosarcoma, 20×
Figure 5
Figure 5
α SMA positive myofibroblasts in odontogenic keratocyst, 10×
Figure 6
Figure 6
α SMA positive myofibroblasts in squamous cell carcinoma, 20×
Figure 7
Figure 7
Giant cell fibroblasts in subepithelial region, 20×
Figure 8
Figure 8
Giant cell fibroblasts, 40×
See this image and copyright information in PMC

References

    1. Lekic PC, Pender N, McCulloch CA. Is fibroblast heterogeneity relevant to the health, diseases and treatments of periodontal tissues? Crit Rev Oral Biol Med. 1997;8:253–68. - PubMed
    1. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med. 1994;1:71–81. - PMC - PubMed
    1. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites. J Immunol. 2001;166:7556–62. - PubMed
    1. Majno G, Gabbiani G, Hirschel BJ, Ryan GB, Statkov PR. Contraction of granulation tissue in vitro: similarity to smooth muscle. Science. 1971;173:548–50. - PubMed
    1. Gabbiani G, Chaponnier C, Huttner I. Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing. J Cell Biol. 1978;76:561–8. - PMC - PubMed