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Meta-Analysis
. 2012 Apr 14;18(14):1672-9.
doi: 10.3748/wjg.v18.i14.1672.

Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis

Yong-Heng Bai  1 , Hong Lu, Dan Hong, Cheng-Cheng Lin, Zhen Yu, Bi-Cheng Chen
Affiliations
Meta-Analysis

Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis

Yong-Heng Bai et al. World J Gastroenterol. .

Abstract

Aim: To investigate the relationship between polymorphisms present in the vitamin D receptor (VDR) gene and colorectal cancer risk, a systematic meta-analysis of population-based studies was performed.

Methods: A total of 38 relevant reports published between January 1990 and August 2010 were identified, of which only 23 qualified for this meta-analysis based on our selection criteria. Five polymorphic variants of the VDR gene, including Cdx-2 (intron 1e) and FokI (exon 2) present in the 5' region of the gene, and BsmI (intron 8), ApaI (intron 8), and TaqI (exon 9) sites present in the 3' untranslated region (UTR), were evaluated for possible associations with colorectal cancer risk. Review manager 4.2 was used to perform statistical analyses.

Results: In the meta-analysis performed, only the BsmI polymorphism was found to be associated with colorectal cancer risk. In particular, the BsmI B genotype was found to be related to an overall decrease in the risk for colorectal cancer [BB vs bb: odds ratio (OR) = 0.87, 95% CI: 0.80-0.94, P = 3 × 10(-4); BB vs Bb + bb: OR = 0.90, 95% CI: 0.84-0.97, P = 5 × 10(-4)]. Moreover, in subgroup analyses, the BsmI B genotype was significantly associated with colon cancer, and not rectal cancer. An absence of between-study heterogeneity was also observed.

Conclusion: A meta-analysis of 23 published studies identified the BsmI polymorphism of the VDR gene to be associated with an increased risk of colon cancer.

Keywords: Colorectal cancer; Meta-analysis; Polymorphism; Vitamin D receptor.

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Figures

Figure 1
Figure 1
A funnel plot was used to estimate the publication bias of the studies included in the meta-analysis performed.
Figure 2
Figure 2
Forest plot of the meta-analysis performed to investigate the association between the BsmI polymorphism of the vitamin D receptor gene and colorectal cancer risk (fixed-effects model).
See this image and copyright information in PMC

References

    1. World Health Organization. Cancer. Fact sheet N°297. February. 2012. Available from: http://www.who.int/mediacentre/factsheets/fs297/en.
    1. American Cancer Society. Cancer Facts and Figures. 2009. Available from: http://www.cancer.org/Research/CancerFactsFigures/index.
    1. Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980;9:227–231. - PubMed
    1. Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann N Y Acad Sci. 1999;889:107–119. - PubMed
    1. Vandewalle B, Adenis A, Hornez L, Revillion F, Lefebvre J. 1,25-dihydroxyvitamin D3 receptors in normal and malignant human colorectal tissues. Cancer Lett. 1994;86:67–73. - PubMed

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