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Review
. 2012 Apr 24;50(1):20-4.
doi: 10.2478/18692.

Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Alina Minarowska  1 , Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko
Affiliations
Free article
Review

Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Alina Minarowska et al. Folia Histochem Cytobiol. .
Free article

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).

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