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Review
. 2012 May;53(5):771-8.
doi: 10.1111/j.1528-1167.2012.03462.x.

The system epilepsies: a pathophysiological hypothesis

Giuliano Avanzini  1 , Paolo Manganotti, Stefano Meletti, Solomon L Moshé, Ferruccio Panzica, Peter Wolf, Giuseppe Capovilla
Affiliations
Review

The system epilepsies: a pathophysiological hypothesis

Giuliano Avanzini et al. Epilepsia. 2012 May.

Abstract

We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

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