Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug 30;199(1):74-6.
doi: 10.1016/j.psychres.2012.03.048. Epub 2012 Apr 24.

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Jeffrey R Bishop  1 , Sharon S Chae, Shitalben Patel, Jessica Moline, Vicki L Ellingrod
Affiliations

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Jeffrey R Bishop et al. Psychiatry Res. .

Abstract

We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

PubMed Disclaimer

References

    1. Bishop JR, Ellingrod VL, Akroush M, Moline J. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives. Hum Psychopharmacol. 2009;24:207–215. - PMC - PubMed
    1. Bull SA, Hu XH, Hunkeler EM, Lee JY, Ming EE, Markson LE, Fireman B. Discontinuation of use and switching of antidepressants: influence of patient-physician communication. JAMA. 2002a;288:1403–1409. - PubMed
    1. Bull SA, Hunkeler EM, Lee JY, Rowland CR, Williamson TE, Schwab JR, Hurt SW. Discontinuing or switching selective serotonin-reuptake inhibitors. Ann Pharmacother. 2002b;36:578–584. - PubMed
    1. Clayton AH, McGarvey EL, Clavet GJ. The Changes in Sexual Functioning Questionnaire (CSFQ): development, reliability, and validity. Psychopharmacol Bull. 1997;33:731–745. - PubMed
    1. Dominguez JM, Gil M, Hull EM. Preoptic glutamate facilitates male sexual behavior. J Neurosci. 2006;26:1699–1703. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources