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. 2012 Jun;169(6):642-9.
doi: 10.1176/appi.ajp.2012.11081245.

Differing amygdala responses to facial expressions in children and adults with bipolar disorder

Pilyoung Kim  1 , Laura A Thomas, Brooke H Rosen, Alexander M Moscicki, Melissa A Brotman, Carlos A Zarate Jr, R James R Blair, Daniel S Pine, Ellen Leibenluft
Affiliations

Differing amygdala responses to facial expressions in children and adults with bipolar disorder

Pilyoung Kim et al. Am J Psychiatry. 2012 Jun.

Abstract

Objective: Child and adult bipolar patients show both behavioral deficits in face emotion processing and abnormal amygdala activation. However, amygdala function in pediatric relative to adult bipolar patients has not been compared directly. The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects.

Method: Amygdala responses to emotional facial expressions were examined in pediatric (N=18) and adult (N=17) bipolar patients and in healthy child (N=15) and adult (N=22) volunteers. Participants performed a gender identification task while viewing fearful, angry, and neutral faces.

Results: In response to fearful faces, bipolar patients across age groups exhibited right amygdala hyperactivity relative to healthy volunteers. However, when responses to all facial expressions were combined, pediatric patients exhibited greater right amygdala activation than bipolar adults and healthy children.

Conclusions: Amygdala hyperactivity in response to fearful faces is present in both youths and adults with bipolar disorder. However, compared with bipolar adults and healthy child volunteers, pediatric bipolar patients showed amygdala hyperactivity in response to a broad array of emotional faces. Thus, abnormal amygdala activation during face processing appears to be more pervasive in children than in adults with bipolar disorder. Longitudinal studies are needed to elucidate the mechanisms of this developmental difference, thus facilitating developmentally sensitive diagnosis and treatment.

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Figures

Figure 1
Figure 1
Findings of right amygdala ROI analysis A. Right amygdala mask B. Age-group X diagnosis interaction (F=4.30, df=1,64, p=.04). BOLD responses across expressions in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response. C. Emotion X diagnosis interaction (F=4.52, df=2,128, p=.01). BOLD responses to fearful, angry and neutral expressions across age groups in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response.
Figure 1
Figure 1
Findings of right amygdala ROI analysis A. Right amygdala mask B. Age-group X diagnosis interaction (F=4.30, df=1,64, p=.04). BOLD responses across expressions in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response. C. Emotion X diagnosis interaction (F=4.52, df=2,128, p=.01). BOLD responses to fearful, angry and neutral expressions across age groups in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response.
Figure 1
Figure 1
Findings of right amygdala ROI analysis A. Right amygdala mask B. Age-group X diagnosis interaction (F=4.30, df=1,64, p=.04). BOLD responses across expressions in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response. C. Emotion X diagnosis interaction (F=4.52, df=2,128, p=.01). BOLD responses to fearful, angry and neutral expressions across age groups in right amygdala. The error bars represent the standard deviation of the mean % signal change BOLD response.
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References

    1. Kohler CG, Hoffman LJ, Eastman LB, Healey K, Moberg PJ. Facial emotion perception in depression and bipolar disorder: A quantitative review. Psychiatry Res. in press. - PubMed
    1. Chen CH, Suckling J, Lennox BR, Ooi C, Bullmore ET. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord. 2011;13:1–15. - PubMed
    1. Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston EE, et al. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry. 2009;66:516–21. - PMC - PubMed
    1. Correll CU, Sheridan EM, DelBello MP. Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo-controlled trials. Bipolar Disord. 2010;12:116–41. - PubMed
    1. Axelson D, Birmaher B, Strober M, Gill MK, Valeri S, Chiappetta L, et al. Phenomenology of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry. 2006;63:1139–48. - PubMed

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