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. 2012 Dec;68(4):611-8.
doi: 10.1007/s13105-012-0166-y. Epub 2012 Apr 26.

Regulatory long non-coding RNA and its functions

Yong Huang  1 , Ning Liu, Jian Ping Wang, Yu Qin Wang, Xue Li Yu, Zhan Bin Wang, Xiang Chao Cheng, Quan Zou
Affiliations

Regulatory long non-coding RNA and its functions

Yong Huang et al. J Physiol Biochem. 2012 Dec.

Abstract

The discovery of large numbers of long non-coding RNAs (lncRNAs) has been driven by genome-wide transcriptional analyses. Compared to small ncRNAs, lncRNAs have been shown to harbor biological activities, but the functions of the great majority of lncRNAs are not known. There is growing evidence that lncRNAs can regulate gene expression at epigenetic, transcription, and post-transcription levels and widely take part in various physiological and pathological processes, such as participating in cell development, immunity, oncogenesis, clinical disease processes, etc. Here, the current research efforts on the function of lncRNA in recent years were summarized.

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Figures

Fig. 1
Fig. 1
Paradigms for functions of lncRNAs
Fig. 2
Fig. 2
Functions of viral lncRNAs in evading host defenses
See this image and copyright information in PMC

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