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. 2012:6:473-8.
doi: 10.2147/OPTH.S28938. Epub 2012 Mar 23.

Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening

Güngör Sobacı  1 , Gökhan Ozge, Fatih Ç Gündoğan
Affiliations

Cone dysfunctions in retinitis pigmentosa with retinal nerve fiber layer thickening

Güngör Sobacı et al. Clin Ophthalmol. 2012.

Abstract

Purpose: To investigate whether or not thicker retinal nerve fiber layer (RNFL) in retinitis pigmentosa (RP) patients relates to functional abnormalities of the photoreceptors.

Methods: Optical coherence tomography-based RNFL thickness was measured by Stratus-3™ (Zeiss, Basel, Switzerland) optical coherence tomography and electroretinogram (ERG) recordings made using the RETI-port(®) system (Roland, Wiesbaden, Germany) in 27 patients with retinitis pigmentosa and in 30 healthy subjects.

Results: Photopic ERG b-wave amplitude, cone ERG b-wave latency, 30 Hz flicker amplitude, and 30 Hz flicker latency had significant correlations to the RNFL-temporal (r = -0.55, P = 0.004, r = 0.68, P = 0.001, r = -0.65, P = 0.001, and r = -0.52, P = 0.007, respectively). Eyes with thicker RNFL (ten eyes) differed significantly from those with thinner RNFL (eight eyes) regarding cone ERG b-wave latency values only (P = 0.001).

Conclusion: Thicker RNFL in patients with retinitis pigmentosa may be associated with functional abnormality of the cone system.

Keywords: b-wave; electroretinography; optical coherence tomography; photoreceptor.

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Figures

Figure 1
Figure 1
Retinitis pigmentosa (RP) patient with (A) thicker retinal nerve fiber layer (RN FL) (B) and flash electroretinogram (ERG).
Figure 1
Figure 1
Retinitis pigmentosa (RP) patient with (A) thicker retinal nerve fiber layer (RN FL) (B) and flash electroretinogram (ERG).
Figure 2
Figure 2
Correlations of cone electroretinogram b-wave latency to thicker retinal nerve fiber layer-temporal thickness.
See this image and copyright information in PMC

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