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. 2012 Jul;26(7):919-24.
doi: 10.1038/eye.2012.59. Epub 2012 Apr 27.

Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13

A Domalpally  1 , Q Peng, R Danis, B Blodi, I U Scott, M Ip; SCORE Study Research Group
Affiliations

Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13

A Domalpally et al. Eye (Lond). 2012 Jul.

Abstract

Purpose: To assess associations between visual acuity (VA) and the status of the photoreceptor inner segment-outer segment (IS-OS) junction in a subset of patients in the Standard Care vs COrticosteroid for REtinal Vein Occlusion (SCORE) Study.

Methodology: High-resolution time domain optical coherence tomography (OCT) scans of study eyes from a single site participating in the SCORE Study were evaluated. Integrity of the IS-OS junction in the central subfield was evaluated using a three-step scale: absent, abnormal or normal. Associations of the IS-OS status with ETDRS VA letter score and center point thickness (CPT) were investigated.

Results: Baseline OCTs of 42 eyes were evaluated. The IS-OS junction was absent in 30 (71%) and abnormal in 12 (29%). At month 12, the IS-OS junction was absent in 18 (43%), abnormal in 12 (28%), and normal in 12 (28%) eyes. At baseline, IS-OS status was significantly associated with CPT, but not with VA. At month 12, IS-OS status was significantly associated with CPT and VA, that is, absent or abnormal IS-OS was associated with increased CPT and worse VA. Change in IS-OS status was not associated with change in CPT (P=0.8). Worsening of IS-OS status was associated with loss of VA and improvement in IS-OS status to normal was associated with gain in VA (P=0.03).

Conclusion: In this data set with long-term follow-up of OCTs as part of the SCORE Study, there is a correlation between change in IS-OS status and VA. This supports further evaluation of outer retinal morphology in larger data sets.

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Figures

Figure 1
Figure 1
Evaluation of the photoreceptor inner segment–outer segment (IS–OS) status using the three step scale; left normal IS–OS, centre abnormal IS–OS and right absent IS–OS.
See this image and copyright information in PMC

References

    1. Ip MS, Oden NL, Scott IU, Vanveldhuisen PC, Blodi BA, Figueroa M, et al. SCORE Study Report 3 Study Design and Baseline Characteristics. Ophthalmology. 2009;116 (9:1770–1777. - PMC - PubMed
    1. DRCRnet. A. Randomized Trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology. 2008;115 (9:1447–1459. - PMC - PubMed
    1. Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117 (6:1064–1077. - PMC - PubMed
    1. Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143 (4:566–583. - PubMed
    1. Altaweel MM, Hubbard L, Gagnon R, Eyetech Study Group The utility of optical coherence tomography in eligibility determination for clinical trials of macular disease therapy. invest Invest Ophthalmol Vis Sci 200546E-Abstract1577

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