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. 2012 Jun 7;48(45):5575-7.
doi: 10.1039/c2cc31710a. Epub 2012 Apr 26.

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

Colin L Walsh  1 , Juliane Nguyen, Francis C Szoka
Affiliations

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

Colin L Walsh et al. Chem Commun (Camb). .

Abstract

We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.

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