Comment
doi: 10.1038/ng.2255.
Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor
Affiliations
- PMID: 22538718
- DOI: 10.1038/ng.2255
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Comment
Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor
Nat Genet.
.
Abstract
Three teams have applied whole-exome and proteome methods to identify a new cofactor of human RNA polymerase II that is required for the recovery of transcription on damaged templates. The identification of this new factor raises questions about the causal relationships between molecular mechanisms of transcription regulation and excision repair and developmental and neurological disease and nonmalignant skin photosensitivity.
Comment on
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Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.Nat Genet. 2012 May;44(5):586-92. doi: 10.1038/ng.2229. Nat Genet. 2012. PMID: 22466610
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UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.Nat Genet. 2012 May;44(5):598-602. doi: 10.1038/ng.2230. Nat Genet. 2012. PMID: 22466611
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Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.Nat Genet. 2012 May;44(5):593-7. doi: 10.1038/ng.2228. Nat Genet. 2012. PMID: 22466612
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