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Editorial
. 2012 Apr 27;110(9):1154-6.
doi: 10.1161/CIRCRESAHA.112.269183.

Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1

Editorial

Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1

Dominic P Del Re et al. Circ Res. .
No abstract available

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Figures

Figure
Figure
A schematic summary of the current findings by Sundararaman et al. Briefly, increased Pim-1 expression in CPCs promotes asymmetrical chromosome segregation, which may explain why Pim-1 can enhance CPC proliferation, selfrenewal and differentiation.

Comment on

References

    1. Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10;379(9819):933–942. - PubMed
    1. Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc. 2007;2(12):3081–3089. - PubMed
    1. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6;142(3):375–386. - PMC - PubMed
    1. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003 Sep 19;114(6):763–776. - PubMed
    1. Tang XL, Rokosh DG, Guo Y, Bolli R. Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction. Circ J. 2010 Mar;74(3):390–404. - PMC - PubMed

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