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Review
. 2012 Aug;16(3-4):429-35.
doi: 10.1016/j.cbpa.2012.03.016. Epub 2012 Apr 26.

DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery

Hang Xing  1 , Ngo Yin Wong, Yu Xiang, Yi Lu
Affiliations
Review

DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery

Hang Xing et al. Curr Opin Chem Biol. 2012 Aug.
No abstract available

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Figures

Figure 1
Figure 1
A general illustration of the three cellular analysis and therapeutic applications of aptamer-functionalized nanoparticles.
Figure 2
Figure 2
(a). Schematic view of the basic design and stimuli-responsive mechanism of aptamer nano-flare. (b). Fluorescence microscopy images of HeLa cells incubated with aptamer nano-flares and control particles. (c). Flow cytometry results of fluorescent intensity (Cy5) of cells treated with aptamer nano-flares and control particles. Adapted from [38].
Figure 3
Figure 3
(a). Schematic illustration of in situ molecular probing in living cells by using aptamer/GO-nS nanocomplex. (b). JB6 cells specific uptake of ATP aptamer-FAM/GO-nS samples (b) and random DNA-FAM/GO-nS samples (c). Images were taken under differential interference contrast and wide-field fluorescence. Adapted from [43**].
Figure 4
Figure 4
(a). Schematic view of self-assembly of aptamer modified, doxorubicin-loaded DNA icosahedra (Doxo@Apt-DNA-icosa). (b). Proposed MUC1 aptamer-mediated endocytosis mechanism of Doxo@Apt-DNA-icosa. Adapted from [56**].
See this image and copyright information in PMC

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