Crucial first steps: the transcriptional control of neuron delamination
- PMID: 22542173
- DOI: 10.1016/j.neuron.2012.04.002
Crucial first steps: the transcriptional control of neuron delamination
Abstract
A crucial event in the birth of a neuron is the detachment of its apical process from the neuroepithelium. In this issue of Neuron, Rousso et al. (2012) show that repression of N-cadherin by Foxp transcription factors disrupts apical adherens junctions and triggers neurogenesis.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.Neuron. 2012 Apr 26;74(2):314-30. doi: 10.1016/j.neuron.2012.02.024. Neuron. 2012. PMID: 22542185 Free PMC article.
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