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Review
. 2012 May;28(2):122-8.
doi: 10.1016/j.soncn.2012.03.007.

Genetic biomarkers of cancer risk

Kathleen A Calzone  1
Affiliations
Review

Genetic biomarkers of cancer risk

Kathleen A Calzone. Semin Oncol Nurs. 2012 May.

Abstract

Objectives: To provide a review of genetic biomarkers of cancer risk and associated clinical implications.

Data sources: Published literature, evidence-based guidelines.

Conclusion: Identification of the genetic variation associated with cancer risk enables the health care provider to stratify an individual's risk and personalize their cancer risk management. This may lead to a decreased cancer incidence in high-risk populations, but at a minimum, will provide the opportunity for early diagnosis that may decrease cancer morbidity and mortality.

Implications for nursing practice: Nursing implications include assessment for cancer risk, initiate referrals indicated, and delivering ongoing education and support for cancer risk management plans.

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Figures

FIGURE 1.
FIGURE 1.
Single nucleotide polymorphisms (SNPs).
FIGURE 2.
FIGURE 2.
ACCE model (analytic validity, clinical validity, clinical utility, and ethical, legal, and social implications) for assessing genetic tests.
See this image and copyright information in PMC

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