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. 2012 Apr 29;44(6):681-4.
doi: 10.1038/ng.2251.

A genome-wide association study identifies susceptibility loci for Wilms tumor

Clare Turnbull  1 , Elizabeth R Perdeaux, David Pernet, Arlene Naranjo, Anthony Renwick, Sheila Seal, Rosa Maria Munoz-Xicola, Sandra Hanks, Ingrid Slade, Anna Zachariou, Margaret Warren-Perry, Elise Ruark, Mary Gerrard, Juliet Hale, Martin Hewitt, Janice Kohler, Sheila Lane, Gill Levitt, Mabrook Madi, Bruce Morland, Veronica Neefjes, James Nicholson, Susan Picton, Barry Pizer, Milind Ronghe, Michael Stevens, Heidi Traunecker, Charles A Stiller, Kathy Pritchard-Jones, Jeffrey Dome, Paul Grundy, Nazneen Rahman
Affiliations

A genome-wide association study identifies susceptibility loci for Wilms tumor

Clare Turnbull et al. Nat Genet. .

Erratum in

  • Nat Genet. 2013 Aug;45(8):962

Abstract

Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10(-5) in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10(-14); rs807624, P = 1.32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.

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Figures

Figure 1
Figure 1. Regional plots of Wilms tumour susceptibility loci at 2p24 and 11q14
The genomic regions of association with Wilms tumor, on chromosomes 2p24 and 11q14. Shown are the −log10 association P values of SNPs in 757 Wilms tumor cases and 1,879 controls. Index SNPs are indicated in blue with the intensity of red shading indicating the strength of LD with the index SNP. Diamond shaped markers indicate genotyped SNPs; circular markers indicate imputed SNPs. Also shown are the SNP build 36 coordinates in kilobases (kb), recombination rates in centimorgans (cM) per megabase (Mb) (in blue) and the genes in the region (in green).
See this image and copyright information in PMC

References

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