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Review
. 2012;6(4):e1601.
doi: 10.1371/journal.pntd.0001601. Epub 2012 Apr 24.

A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes

Affiliations
Review

A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes

James S McCarthy et al. PLoS Negl Trop Dis. 2012.

Abstract

Diagnostic tools appropriate for undertaking interventions to control helminth infections are key to their success. Many diagnostic tests for helminth infection have unsatisfactory performance characteristics and are not well suited for use in the parasite control programmes that are being increasingly implemented. Although the application of modern laboratory research techniques to improve diagnostics for helminth infection has resulted in some technical advances, uptake has not been uniform. Frequently, pilot or proof of concept studies of promising diagnostic technologies have not been followed by much needed product development, and in many settings diagnosis continues to rely on insensitive and unsatisfactory parasitological or serodiagnostic techniques. In contrast, PCR-based xenomonitoring of arthropod vectors, and use of parasite recombinant proteins as reagents for serodiagnostic tests, have resulted in critical advances in the control of specific helminth parasites. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR) was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, the diagnostic technologies relevant to control of helminth infections, either available or in development, are reviewed. Critical gaps are identified and opportunities to improve needed technologies are discussed.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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References

    1. Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, et al. A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis. 2012;6:e1582. doi: 10.1371/journal.pntd.0001582. - DOI - PMC - PubMed
    1. Vercruysse J, Albonico M, Behnke J, Kotze, Prichard R, et al. Is anthelmintic resistance a concern for the control of human soil-transmitted helminths? Int J Parasitol: Drugs and Drug Resistance. 2011;1:14–27. - PMC - PubMed
    1. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, et al. Control of neglected tropical diseases. N Engl J Med. 2007;357:1018–1027. - PubMed
    1. Levecke B, Behnke JM, Ajjampur SS, Albonico M, Ame SM, et al. A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths. PLoS Negl Trop Dis. 2011;5:e1201. doi: 10.1371/journal.pntd.0001201. - DOI - PMC - PubMed
    1. Basáñez MG, McCarthy JS, French MD, Yang GJ, Walker M, et al. A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS Negl Trop Dis. 2012;6:e1548. doi: 10.1371/journal.pntd.0001548. - DOI - PMC - PubMed

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