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Editorial
. 2012 Apr 30;3(2):15.
doi: 10.1186/scrt106.

Colonizing the heart from the epicardial side

Nenad Bursac  1
Affiliations
Editorial

Colonizing the heart from the epicardial side

Nenad Bursac. Stem Cell Res Ther. .

Abstract

The clinical use of stem cells, such as bone marrow-derived and, more recently, resident cardiac stem cells, offers great promise for treatment of myocardial infarction and heart failure. The epicardium-derived cells have also attracted attention for their angiogenic paracrine actions and ability to differentiate into cardiomyocytes and vascular cells when activated during cardiac injury. In a recent study, Chong and colleagues have described a distinct population of epicardium-derived mesenchymal stem cells that reside in a perivascular niche of the heart and have a broad multilineage potential. Exploring the therapeutic capacity of these cells will be an exciting future endeavor.

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Comment on

  • Adult cardiac-resident MSC-like stem cells with a proepicardial origin.
    Chong JJ, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, Heffernan C, Menon MK, Scarlett CJ, Rashidianfar A, Biben C, Zoellner H, Colvin EK, Pimanda JE, Biankin AV, Zhou B, Pu WT, Prall OW, Harvey RP. Chong JJ, et al. Cell Stem Cell. 2011 Dec 2;9(6):527-40. doi: 10.1016/j.stem.2011.10.002. Cell Stem Cell. 2011. PMID: 22136928 Free PMC article.

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