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. 2012 Sep 1;17(5):e907-11.
doi: 10.4317/medoral.18136.

Osseous reaction to implantation of two endodontic cements: Mineral trioxide aggregate (MTA) and calcium enriched mixture (CEM)

Saeed Rahimi  1 , Hadi Mokhtari, Shahriar Shahi, Ali Kazemi, Saeed Asgary, Mohammad-Jafar Eghbal, Mehran Mesgariabbasi, Daryoush Mohajeri
Affiliations

Osseous reaction to implantation of two endodontic cements: Mineral trioxide aggregate (MTA) and calcium enriched mixture (CEM)

Saeed Rahimi et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Aim: The aim of the present in vivo study was to determine bone tissue reaction to calcium enriched mixture (CEM) and mineral trioxide aggregate (MTA) using a rat femur model.

Study design: Sixty-three rats were selected and randomly divided into three groups of 21 each [experimental groups (n=15), control (n=6)]. Implantation cavities were prepared in each femoral bone and randomly filled with the biomaterials only in the experimental groups. The animals in three groups were sacrificed 1, 4, and 8 weeks postoperatively. Histologic evaluations comprising inflammation severity and new bone formation were blindly made on H&E-stained decalcified 6-µm sections.

Results: At 1, 4, and 8 weeks after implantation number of inflammatory cells had decreased in the CEM, MTA and control groups, respectively, with no statistically significant differences. Conversely, new bone formation had increased in all the experimental and control groups, without statistically significant differences.

Conclusion: The results suggest that biocompatibility of MTA, as gold standard, and CEM cement as a new endodontic biomaterial are comparable.

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Figures

Figure 1
Figure 1
Histologic images of inflammatory cell infiltration and bone formation around experimental and control groups (hematoxylin and eosin staining). (A) 1-week-old CEM specimens; (original magnification, x100). (B) 1-week-old MTA specimens; (original magnification, x40). (C ) 1-week-old control specimens; (original magnification, x100). (D) 4-week-old CEM specimens; (original magnification, new bone tissue formation; F: fibrosis tissue; CB: complete bridge bone formation).x100). (E) 4-week-old MTA specimens; (original magnification, x100). (F) 4-week-old control specimens; (original magnification, x40). (G) 8-week-old CEM specimens; (original magnification, x100). (H) 8-week-old MTA specimens; (original magnification, x100). (I) 8-week-old control specimens; (original magnification, x100). (IO: Intraosseous bone formation; II: inflammatory cell infiltration; GT: granulation tissue; NB: new bone formation; CB: complete bone bridge formation; F: fibrosis tissue).
See this image and copyright information in PMC

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