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. 2012 Jun 7;48(45):5614-6.
doi: 10.1039/c2cc31975f. Epub 2012 May 1.

Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Phillip J Milnes  1 , Mireya L McKee, Jonathan Bath, Lijiang Song, Eugen Stulz, Andrew J Turberfield, Rachel K O'Reilly
Affiliations

Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Phillip J Milnes et al. Chem Commun (Camb). .

Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

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