HOT DNAs: a novel class of developmental enhancers
- PMID: 22549952
- PMCID: PMC3347785
- DOI: 10.1101/gad.192583.112
HOT DNAs: a novel class of developmental enhancers
Abstract
Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.
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Comment on
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HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature.Genes Dev. 2012 May 1;26(9):908-13. doi: 10.1101/gad.188052.112. Epub 2012 Apr 12. Genes Dev. 2012. PMID: 22499593 Free PMC article.
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