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Comment
. 2012 May 15;109(20):7589-90.
doi: 10.1073/pnas.1205361109. Epub 2012 May 1.

Microbial genome mining answers longstanding biosynthetic questions

Jason M Crawford  1 , Jon Clardy
Affiliations
Comment

Microbial genome mining answers longstanding biosynthetic questions

Jason M Crawford et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Biosynthetic highlights for stipitatic acid. Inset: The arrangement of biosynthetic domains that lead to the production of 3-methylorcinaldehyde (1). Key oxidizing enzymes, their reactions, and important by-products: three oxidative enzymes, TropB, TropC, and TropD, convert 3-methylorcinaldehyde (1) to tropolone 5. TropC has two functions, the oxidation of a methyl to a hydroxymethyl and the pinacol rearrangement of 3 to 4.
See this image and copyright information in PMC

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References

    1. Nett M, Ikeda H, Moore BS. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep. 2009;26:1362–1384. - PMC - PubMed
    1. Wenzel SC, Müller R. The impact of genomics on the exploitation of the myxobacterial secondary metabolome. Nat Prod Rep. 2009;26:1385–1407. - PubMed
    1. Kalaitzis JA, Lauro FM, Neilan BA. Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways. Nat Prod Rep. 2009;26:1447–1465. - PubMed
    1. Gross H, Loper JE. Genomics of secondary metabolite production by Pseudomonas spp. Nat Prod Rep. 2009;26:1408–1446. - PubMed
    1. Brady SF, Simmons L, Kim JH, Schmidt EW. Metagenomic approaches to natural products from free-living and symbiotic organisms. Nat Prod Rep. 2009;26:1488–1503. - PMC - PubMed

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