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. 2012:2012:345161.
doi: 10.1155/2012/345161. Epub 2012 Apr 1.

Metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience

Naofumi Asano  1 , Michiro Susa, Seiichi Hosaka, Robert Nakayama, Eisuke Kobayashi, Katsuhito Takeuchi, Keisuke Horiuchi, Yoshihisa Suzuki, Ukei Anazawa, Makio Mukai, Yoshiaki Toyama, Hiroo Yabe, Hideo Morioka
Affiliations

Metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience

Naofumi Asano et al. Sarcoma. 2012.

Abstract

Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further divided into three groups; without metastasis, with extrapulmonary metastasis, and with pulmonary metastasis. When the metastatic patterns were stratified according to tumor size, there was statistical significance between the three groups (P = 0.028). The 8 cases with extrapulmonary metastases were all larger than 10 cm. Similarly, histological grading had a significant impact on metastatic patterns (P = 0.027). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis.

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Figures

Figure 1
Figure 1
(a) Photomicrograph of low-grade MRCL. (b) Photomicrograph of high-grade MRCL.
Figure 2
Figure 2
(a) Correlation of metastatic pattern to tumor size. When the metastatic patterns were stratified according to tumor size (<10 cm or ≥10 cm), there was statistical significance between the groups (P = 0.028). Of the 47 cases without metastases, 14 (38%) were larger than 10 cm. The 8 cases with extrapulmonary metastases were all larger than 10 cm. Only 1 case was larger than 10 cm in the pulmonary metastatic group. (b) Correlation of metastatic pattern to histological grade. Histological grading (low or high) had a significant impact on metastasis patterns (P = 0.027). Of the 8 cases with extrapulmonary metastases, 4 (50%) were pathologically diagnosed as low-grade MRCL and 4 (50%) as high-grade MRCL. The 3 cases with pulmonary metastatic lesions were all diagnosed as high-grade MRCL.
Figure 3
Figure 3
Survival rate. (a) The absolute overall survival rate was 86%. (b) The overall survival rate was significantly better for patients with extrapulmonary metastasis (63%) compared to those with pulmonary metastasis (0%) (P < 0.001).
See this image and copyright information in PMC

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