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. 2010 May;24(2):137-47.
doi: 10.1055/s-0030-1255331.

The role of chemotherapy in the management of patients with head and neck cancer

Panayiotis Panos Savvides  1
Affiliations

The role of chemotherapy in the management of patients with head and neck cancer

Panayiotis Panos Savvides. Semin Plast Surg. 2010 May.

Abstract

Recent advances in the management of patients with head and neck cancer point to an expanding role of chemotherapy, resulting in an increased involvement of the medical oncologist in the multidisciplinary care of these patients. This review focuses on patients with squamous cell carcinoma of the oral cavity, pharynx, and larynx. A comprehensive review of the clinical trial data that have defined new standards of care and a detailed presentation of widely used chemotherapeutic regimens, including both cytotoxic and molecularly targeted agents, are presented. Information on human papilloma virus-associated squamous cell cancer of the head and neck is presented, and implications in the clinical management of this subgroup of patients based on the epidemiologic and pathologic characteristics are discussed.

Keywords: Cancer of the head and neck; chemotherapy; squamous cell carcinoma.

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Figures

Figure 1
Figure 1
Treatment options involving chemotherapy for locally advanced squamous cell carcinoma of the head and neck.
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun M J. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–249. - PubMed
    1. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007;18:581–592. - PubMed
    1. Edwards B K, Brown M L, Wingo P A, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005;97:1407–1427. - PubMed
    1. Kamangar F, Dores G M, Anderson W F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24:2137–2150. - PubMed
    1. Spector J G, Sessions D G, Chao K S, Hanson J M, Simpson J R, Perez C A. Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery. Head Neck. 1999;21:116–123. - PubMed