Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012:2012:805151.
doi: 10.1155/2012/805151. Epub 2012 Apr 8.

Suboptimal immune reconstitution in vertically HIV infected children: a view on how HIV replication and timing of HAART initiation can impact on T and B-cell compartment

Nicola Cotugno  1 , Iyadh Douagi, Paolo Rossi, Paolo Palma
Affiliations
Review

Suboptimal immune reconstitution in vertically HIV infected children: a view on how HIV replication and timing of HAART initiation can impact on T and B-cell compartment

Nicola Cotugno et al. Clin Dev Immunol. 2012.

Abstract

Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconstitute and to mount specific immune responses in children receiving HAART. In this paper, we review the underlying mechanisms of immune reconstitution after HAART initiation among vertically HIV-infected children analyzing the possible causes of suboptimal responses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
How timing of HAART initiation impact on B- and T-cell compartment and on viral replication.
See this image and copyright information in PMC

References

    1. Resino S, Bellón JM, Micheloud D, et al. Clinical outcomes improve with highly active antiretroviral therapy in vertically HIV type-1-infected children. Clinical Infectious Diseases. 2006;43(2):243–252. - PubMed
    1. Haberer J, Mellins C. Pediatric adherence to HIV antiretroviral therapy. Current HIV/AIDS Reports. 2009;6(4):194–200. - PMC - PubMed
    1. Castro H, Judd A, Gibb DM, et al. Risk of triple-class virological failure in children with HIV: a retrospective cohort study. The Lancet. 2011;377(9777):1580–1587. - PMC - PubMed
    1. Guihot A, Tubiana R, Breton G, et al. Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy. AIDS. 2010;24(4):614–617. - PubMed
    1. Kaufmann GR, Perrin L, Pantaleo G, et al. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV cohort study. Archives of Internal Medicine. 2003;163(18):2187–2195. - PubMed

Publication types

MeSH terms