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Case Reports
. 2012 May 2:11:146.
doi: 10.1186/1475-2875-11-146.

Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory Coast

Nathalie Wurtz  1 , Aurélie Pascual, Adeline Marin-Jauffre, Housem Bouchiba, Nicolas Benoit, Marc Desbordes, Maryse Martelloni, Vincent Pommier de Santi, Georges Richa, Nicolas Taudon, Bruno Pradines, Sébastien Briolant
Affiliations
Case Reports

Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory Coast

Nathalie Wurtz et al. Malar J. .

Abstract

The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone-proguanil (Malarone®) has shown high efficacy against Plasmodium falciparum with only mild side-effects. Treatment failures have been attributed to suboptimal dosages or to parasite resistance resulting from a point mutation in the cytochrome b gene. In this paper, a case of early treatment failure was reported in a patient treated with atovaquone-proguanil; this failure was not associated with a mutation in the parasite cytochrome b gene, with impaired drug bioavailability, or with re-infection.

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