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Case Reports
. 2012 May 2:4:18.
doi: 10.1186/1758-3284-4-18.

Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma

Wan-Qin Shen  1 , Ke-Jia Cheng, Yang-Yang Bao, Shui-Hong Zhou, Hong-Tian Yao
Affiliations
Case Reports

Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma

Wan-Qin Shen et al. Head Neck Oncol. .

Expression of concern in

  • Comment: Head and Neck Oncology.
    BioMed Central. BioMed Central. BMC Med. 2014 Feb 5;12:24. doi: 10.1186/1741-7015-12-24. BMC Med. 2014. PMID: 24499430 Free PMC article. Review.

Abstract

Objectives: Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker.

Case report: A 78-year-old man presented with a 6-month history of recurrent otorrhoea in the right ear. Surgery was performed by the transmeatal approach with total removal of the mass. Histopathology revealed a ceruminous adenoma. Tumour cells were positive for CK, S-100 protein, Glut-1, HIF-1α, PI3K and p-Akt. There was no evidence of recurrence at last follow-up 27 months after the operation.

Conclusions: Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC.

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Figures

Figure 1
Figure 1
CT showed a 0.5×0.5cm soft lesion in the right EAC with no signs of bone destruction.
Figure 2
Figure 2
Immunohistochemistry analyses for the expression of Glut-1, HIF-1α, PI3K and p-Akt. The tumor cells were positive for Glut-1(A) (EliVision×20), HIF-1α(B) (EliVision×10), PI3K(C) (EliVision×40) and p-Akt(D) (EliVision×10).
See this image and copyright information in PMC

References

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