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Review
. 2012 May;200(5):380-7.
doi: 10.1097/NMD.0b013e3182531f17.

The increasing frequency of mania and bipolar disorder: causes and potential negative impacts

Sean H Yutzy  1 , Chad R Woofter, Christopher C Abbott, Imad M Melhem, Brooke S Parish
Affiliations
Review

The increasing frequency of mania and bipolar disorder: causes and potential negative impacts

Sean H Yutzy et al. J Nerv Ment Dis. 2012 May.

Abstract

The frequency of mania has not changed during the last century even with the development of new diagnostic criteria sets. More specifically, from the mid-1970s to 2000, the rate of mania (variably labeled major affective disorder-bipolar disorder and bipolar I disorder) was consistently identified in US and international studies as ranging from 0.4% to 1.6%. By the late 1990s to the 2000s, the prevalence reported by some researchers for bipolar disorders (I and II and others) was in the 5% to 7% and higher ranges. The purpose of this paper was to review explanations for this change and the potentially negative impacts on the field.

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Conflict of interest statement

DISCLOSURE

The authors declare no conflict of interest.

References

    1. Akiskal HS. The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV. J Clin Psychopharmacol. 1996;16:4S–14S. - PubMed
    1. Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfeld R. Reevaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord. 2000;59:S5–S30. - PubMed
    1. Akiskal HS, Mallya G. Criteria for the ‘soft’ bipolar spectrum: Treatment implications. Psychopharmacol Bull. 1987;23:68–73. - PubMed
    1. Akiskal HS, Pinto O. The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatr Clin North Am. 1999;22:517–534. vii. - PubMed
    1. Alexander F, Selsnick S. The history of psychiatry. New York, NY: Harper & Row; 1966.