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. 2012 Jul;23(7):1629-35.
doi: 10.1007/s10856-012-4656-9. Epub 2012 May 3.

Characterization and photodynamic activity of a new phthalocyanine nanoparticles

Rui Lin  1 , Lin Zhou, Ke-Long Fang, Yun Lin, Ao Wang, Jia-Hong Zhou, Shao-Hua Wei
Affiliations

Characterization and photodynamic activity of a new phthalocyanine nanoparticles

Rui Lin et al. J Mater Sci Mater Med. 2012 Jul.

Abstract

Nanoparticles of a hydrophobic photosensitizer, tetrakis (3-trifluoromethylphenoxy) zinc phthalocyanine (FPcZn) have been synthesized by using a simple reprecipitation technique. The resulting drug nanoparticles (FPcZn-NP) were spherical, highly monodispersed and stable in aqueous system, without an additional stabilizer. Comparative studies with FPcZn-NP and FPcZn indicated that after the formation of nanoparticles, FPcZn-NP maintained the efficiency of (1)O(2) generation. Further more, the in vitro studies demonstrated that such nanoparticles can be efficiently taken up by Hela cells, which might be resulted to cell death by light irradiation. These properties could make the FPcZn-NP to be a promising candidate in clinical photodynamic therapy.

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