Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;3(2):141-4.
doi: 10.3980/j.issn.2222-3959.2010.02.11. Epub 2010 Jun 18.

F-heparin modified intraocular lenses in Rhesus monkeys

Gui-Qin Wang  1 , Han-Qing Gu, Jia-Qin Yuan, Hui-Min Sun, Yan-Shan Xu
Affiliations

F-heparin modified intraocular lenses in Rhesus monkeys

Gui-Qin Wang et al. Int J Ophthalmol. 2010.

Abstract

Aim: In order to improve the biocompatibility of intraocular lenses (IOL), the polymethylmethacrylate (PMMA) IOL was modified with F-heparin.

Methods: The PMMA IOL was modified with F ions and heparin by the technique of ion beam combined with low temperature and low pressure plasma. The monkeys (20 eyes) with cataract partly were randomly classified into 2 groups and implanted with PMMA IOL and modified IOL respectively for 180 days. All of the eyes were examined by slit-lamp microscope at postoperative 15, 30, 60, 90, 180 days. The extracted IOL was analyzed with computer image analysis, light microscope (LM) and scanning electron microscope (SEM) at postoperative 180 days.

Results: The early inflammatory reactions postoperatively include anterior chamber exudation and aqueous cell count. The modified IOL group showed less than the non-modified IOL group. The late foreign body cell reaction that adhered to the surface of non-modified IOL was more predominant. The morphologic and pathological changes of posterior capsule opacification (PCO) in monkeys' eyes included fibrosis-type, pearl-type and soemmerring's ring. There was a significant difference between the two groups.

Conclusion: F-heparin modified IOL has good uveal and capsular biocompatibility.

Keywords: F-heparin; Rhesus monkeys; biocompatibility; intraocular lenses; surface modification.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Surface deposited of IOL
A: non-modified; B: modified
Figure 2
Figure 2. Surface adherence of IOL
A: non-modified (SEM×3 000); B: modified (SEM×2 000)
Figure 3
Figure 3. Surface adherence of IOL
A: non-modified (LM×30); B: modified (LM×30)
See this image and copyright information in PMC

References

    1. Abela-Formanek C, Amon M, Schild G, Schauersberger J, Heinze G, Kruger A. Uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses. J Cataract Refract Surg. 2002;28:50–61. - PubMed
    1. Tehrani M, Dick HB, Wolters B, Pakula T, Wolf E. Material properties of various intraocular lenses in an experimental study. Ophthalmologica. 2004;218:57–63. - PubMed
    1. Zetterstrom C, Lundvall A, Olivestedt G. Exfoliation syndrome and heparin surface modified intraocular lenses. Acta Ophthalmologica. 1992;70:91–95. - PubMed
    1. Spängberg M, Kihlström I, Björklund H, Bjurström S, Lydahl E, Larsson R. Improved biocompatibility of intraocular lenses by heparin surface modification: a 12-month implantation study in monkeys. J Cataract Refract Surg. 1990;16:170–177. - PubMed
    1. Amon M. Biocompatibility of Intraocular Lenses. J Cataract Refract Surg. 2001;27:178–179. - PubMed

LinkOut - more resources