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. 2010;3(2):149-51.
doi: 10.3980/j.issn.2222-3959.2010.02.13. Epub 2010 Jun 18.

Ocular manifestations of Alport syndrome

Jian-Min Xu  1 , Shi-Sheng Zhang, Qiong Zhang, Ying-Ming Zhou, Cai-Hong Zhu, Jian Ge, Ling Wang
Affiliations

Ocular manifestations of Alport syndrome

Jian-Min Xu et al. Int J Ophthalmol. 2010.

Abstract

Aim: To analyze the clinical manifestation of Alport syndrome, especially the ocular features.

Methods: The physical, ophthalmologic and audiologic examination results of thirty-two patients with Alport syndrome were analyzed retrospectively.

Results: Thirty (93.7%) patients had some family history. All patients had renal disease: eighteen (56.3%) patients with chronic renal failure, four (12.5%) patients with renal insufficiency, and the other ten (31.3%) patients with hematuria. Twenty (62.5%) patients had sensorineural deafness. Thirteen (40.6%) patients had ocular deformity, five (15.7%) patients had typical ocular changes: three patients with anterior lenticonus, and two patients with macular flecks.

Conclusion: Ocular anomalies are not requisite for the diagnosis of Alport syndrome. But its typical ocular features should be recognized by the ophthalmologists which supports the diagnosis.

Keywords: Alport syndrome; anterior lenticonus; macular flecks.

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