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. 2011;4(3):286-92.
doi: 10.3980/j.issn.2222-3959.2011.03.16. Epub 2011 Jun 18.

Comparison of age-related changes between corneal and ocular aberration in young and mid-age myopic patients

Feng-Ju Zhang  1 , Zheng Zhou, Fang-Lei Yu, Zhi-Li Lu, Ting Li, Meng-Meng Wang
Affiliations

Comparison of age-related changes between corneal and ocular aberration in young and mid-age myopic patients

Feng-Ju Zhang et al. Int J Ophthalmol. 2011.

Abstract

Aim: To study the dynamic character of aberration between the cornea and the ocular with aging, and to evaluate the symmetry of the aberrations between right and left eye in order to supply the data for clinic to do the refractive surgery reasonably.

Methods: This is a comparative case series study. 82 normal cases (164 eyes) including 37 females (74 eyes) and 45 males (90 eyes) were recruited through the routine examinations, Topolyzer and wavefront analysis. The average age was 25.9±5.0 years old (range 18 to 49 years old), and the mean spherical equivalent (SE) is -3.82±2.21D (range -1.00 to -6.00D). The changes of aberrations regarding age, the relationship between anterior corneal and total aberrations were analyzed, as well as the symmetry between right and left eyes by using Zernike terms.

Results: The Z(3) (1), RMS3 of corneal aberrations, Z(3) (1), Z(4) (0) , RMS3 and RMS4 of ocular aberrations had a positive correlation with age. The zernike terms both in corneal and whole eye were significantly correlated between right and left eyes.

Conclusion: The corneal horizontal coma, ocular horizontal coma and ocular spherical aberrations become to increase at the age of more than 40 years old. The dynamic change of aberration with aging, balance between corneal and ocular, and the symmetric character between left eye and right eye should be designed carefully in the treatment nomogram before the refractive surgery.

Keywords: aberration; age; change; character; cornea; ocular.

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Figures

Figure 1
Figure 1. Correlation between age and comalike aberration Z31 of cornea. There is a statistically significant correlation between age and corneal comalike aberration (r=0.307; P<0.01)
Figure 2
Figure 2. Correlation between age and comalike aberration Z31 of ocular. There is a statistically significant correlation between age and ocular coma aberration (r=0.451; P<0.01)
Figure 3
Figure 3. Correlation between age and spherical aberration Z40 of ocular. There is a statistically significant correlation between age and ocular spherical aberration (r=0.438; P<0.01)
Figure 4
Figure 4. The high-order Zernike coefficients were compared between cornea and ocular in young group. There was no statistically significant correlation between corneal and ocular coma aberration Z31 (P>0.05). The mean absolute values of the ocular coefficient of spherical aberration Z40 (t=2.360, P<0.05) of young subjects were significantly reduced compared to corneal coefficients
Figure 5
Figure 5. The high-order Zernike coefficients were compared between cornea and ocular in middle-aged group. There was still no statistically significant correlation between corneal and ocular coma aberration Z31 (P>0.05). The mean absolute values of the ocular coefficient of spherical aberration Z40 (P>0.05) of young subjects had no significantly difference compared to corneal coefficients
Figure 6
Figure 6. The individual Zernike coefficients Z3−1 of corneal aberration were plotted between bilateral eyes, showing the correlation between left and right eyes
Figure 7
Figure 7. The individual Zernike coefficients Z31 of ocular aberration were plotted between bilateral eyes, showing the correlation between left and right eyes
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