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Review

Data Standardization for Results Management

Robert M. Campbell  1 , Julia Dymshitz  2 , Brian J. Eastwood  2 , Renee Emkey  3 , David P. Greenen  1 , Julia M. Heerding  1 , Dwayne Johnson  1 , Thomas H. Large  4 , Thomas Littlejohn  1 , Chahrzad Montrose  1 , Suzanne E. Nutter  1 , Barry D. Sawyer  1 , Sandra K. Sigmund  1 , Martin Smith  1 , Jeffrey R. Weidner  5 , Richard W. Zink  1
Sarine Markossian  1 , Abigail Grossman  1 , Hannah Baskir  1 , Michelle Arkin  2 , Douglas Auld  3 , Christopher Austin  4 , Jonathan Baell  5 , Kyle Brimacombe  1 , Thomas D.Y. Chung  6 , Nathan P. Coussens  7 , Jayme L. Dahlin  8 , Viswanath Devanarayan  9 , Timothy L. Foley  10 , Marcie Glicksman  11 , Kirill Gorshkov  12 , Stefan Grotegut  13 , Matthew D. Hall  1 , Samuel Hoare  14 , James Inglese  1 , Philip W. Iversen  15 , Madhu Lal-Nag  16 , Zhuyin Li  12 , Jason R. Manro  13 , James McGee  17 , Allison Norvil  13 , Mackenzie Pearson  13 , Terry Riss  18 , Peter Saradjian  19 , G. Sitta Sittampalam  20 , Michael A. Tarselli  21 , O. Joseph Trask Jr.  22 , Jeffrey R. Weidner  23 , Mary Jo Wildey  24 , Kelli Wilson  1 , Menghang Xia  1 , Xin Xu  1
, editors.
In: Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004.
[updated ].
Affiliations
Review

Data Standardization for Results Management

Robert M. Campbell et al.

Excerpt

Raw data collected in screening assays should be appropriately analyzed to derive activity expressed as potency or efficacy values of tested compounds (IC50 or EC50 values). In this chapter the authors discuss standardized approaches to processing radioligand binding, enzyme and functional assays used in HTS and lead optimization. Detailed account is given in processing normalizing raw data and curve fitting. A glossary is also included defining the terms used for consistency in processing raw data in a standardized manner.

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References

    1. Neubig RR, Spedding M, Kenakin T, Christopoulos A. International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 2003;55(4):597-606. doi: 10.1124/pr.55.4.4. PubMed PMID: WOS:000186910700007. - DOI - PubMed