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. 2012 May;86(5):837-42.
doi: 10.4269/ajtmh.2012.11-0446.

Molecular identification of human hookworm infections in economically disadvantaged communities in Peninsular Malaysia

Romano Ngui  1 , Lee Soo Ching, Tan Tiong Kai, Muhammad Aidil Roslan, Yvonne A L Lim
Affiliations

Molecular identification of human hookworm infections in economically disadvantaged communities in Peninsular Malaysia

Romano Ngui et al. Am J Trop Med Hyg. 2012 May.

Abstract

Species identification of human hookworm infections among eight communities in rural areas of Peninsular Malaysia was determined during 2009-2011. Fecal samples were examined by microscopy and subsequently, the internal transcribed spacer 2 and 28S ribosomal RNA region of Necator americanus and Ancylostoma spp. were sequenced. Overall, 9.1% (58 of 634) were identified positive by microscopy for hookworm infection, and 47 (81.0%) of 58 were successfully amplified and sequenced. Sequence comparison found that N. americanus (87.2%) was the most predominant hookworm identified, followed by Ancylostoma ceylanicum (23.4%). No A. duodenale infection was detected in this study. Detection of A. ceylanicum in humans highlighted the zoonotic transmission among humans living near dogs. Thus, implementation of effective control measures for hookworm infections in future should seriously consider this zoonotic implication.

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Figures

Figure 1.
Figure 1.
Location of the study areas in Peninsular Malaysia.
See this image and copyright information in PMC

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