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Comment
. 2012 May 4;336(6081):546-7.
doi: 10.1126/science.1222540.

Cell biology. Superresolution subspace signaling

W Jonathan Lederer  1 , Brian M Hagen, Guiling Zhao
Affiliations
Comment

Cell biology. Superresolution subspace signaling

W Jonathan Lederer et al. Science. .
No abstract available

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Figures

Figure
Figure. Arterial relaxation
The superresolution signaling system in vascular endothelial cells may be organized with respect to smooth muscle cells. Sonkusare et al. examined 100-μm-diameter arterioles in mice. Cooperative gating of clustered TRPV4 channels of a vascular endothelial cell (EC) allows Ca2+ influx. This localized increase in [Ca2+]I activates local K+ channels, hyperpolarizes endothelial cells, and increases nearby [K+] in the internal elastic lamina (IEL). Activated IP3 Rs in the endothelial cell ER produce locally high [Ca2+]i signals. Locally elevated [K+] increases inward-rectifier K+ channel (Kir) current in the smooth muscle cell (SMC) to hyperpolarize the cells, which underlies vascular relaxation and increased blood flow. ACh, acetylcholine; PIP2, phosphatidylinositol 4,5-bisphosphate. “CREDIT: C. BICKEL/SCIENCE”
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