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. 2012 Apr;28(2):172-7.
doi: 10.4103/0970-9185.94833.

Flupirtine: Clinical pharmacology

S Harish  1 , K Bhuvana, Girish M Bengalorkar, Tn Kumar
Affiliations

Flupirtine: Clinical pharmacology

S Harish et al. J Anaesthesiol Clin Pharmacol. 2012 Apr.

Abstract

Flupirtine is neither an opioid nor a non steroidal anti-inflammatory drug (NSAID) producing its analgesic action through blockade of glutamate N-methyl-D-aspartate receptor. It is devoid of adverse effects of routinely used analgesic drugs, but is equally efficacious in reducing pain sensation. It has a distinctive mechanism of action, exerting a dual therapeutic effect with both analgesic and muscle relaxant properties that has utility in the treatment of pain, including that associated with muscle tension.

Keywords: Flupirtine; N-methyl-D-aspartate receptor; non-steroidal anti-inflammatory drug; opioids.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Structure of flupirtine
See this image and copyright information in PMC

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