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. 2012 Apr;4(2):155-63.
doi: 10.4103/0975-7406.94822.

Development of span 80-tween 80 based fluid-filled organogels as a matrix for drug delivery

Charulata Bhattacharya  1 , Nikhil Kumar, Sai S Sagiri, Kunal Pal, Sirsendu S Ray
Affiliations

Development of span 80-tween 80 based fluid-filled organogels as a matrix for drug delivery

Charulata Bhattacharya et al. J Pharm Bioallied Sci. 2012 Apr.

Abstract

Background: Organogels are defined as 3-dimensional networked structures which immobilize apolar solvents within them. These gelled formulations are gaining importance because of their ease of preparation and inherent stability with improved shelf life as compared to the ointments.

Aim: Development of span 80-tween 80 mixture based organogels for the first time by fluid-filled fiber mechanism.

Materials and methods: Span 80 and tween 80 were used as surfactant and co-surfactant, respectively. The surfactant mixtures were dissolved in oil followed by the addition of water which led to the formation of organogels at specific compositions. The formulations were analyzed by microscopy, X-ray diffraction (XRD), time-dependent stability test and accelerated thermal stability test by thermocycling method. Ciprofloxacin, a fourth-generation fluoroquinolone, was incorporated within the organogels. The antimicrobial activity of the drug loaded organogels and in vitro drug release from the gels was also determined.

Results and conclusions: Microscopic results indicated that the gels contained clusters of water-filled spherical structures. XRD study indicated the amorphous nature of the organogels. The release of the drug was found to be diffusion controlled and showed marked antimicrobial property. In short, the prepared organogels were found to be stable enough to be used as pharmaceutical formulation.

Keywords: Antimicrobial activity and drug release; organogel; span 80; tween 80.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Organogel samples of different composition
Figure 2
Figure 2
Ternary phase diagrams of the (a) G, (b) H and (c) I organogels
Figure 3
Figure 3
Morphological observation of (a) G_1, (b) H_1 and (c) I_1 organogels
Figure 4
Figure 4
Micrographs of (a) G_1, (b) H_1 and (c) I_1 organogels without rhodamine B
Figure 5
Figure 5
Micrographs of H_1 organogel as visualized under (a) confocal microscope and (b) ESEM
Figure 6
Figure 6
XRD graphs of G_1, H_1, I_1, H_1 + D and ciprofloxacin
Figure 7
Figure 7
Normalized XRD graphs of G_1, H_1, I_1 and H_1 + D organogels
Figure 8
Figure 8
Viscosity profile of the organogels
Figure 9
Figure 9
Gel–sol transition temperatures of organogels
Figure 10
Figure 10
In vitro drug release data for ciprofloxacin
See this image and copyright information in PMC

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