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Comparative Study
. 2012;5(3):231-42.
Epub 2012 Mar 25.

The histopathological spectrum of human meningiomas

Thomas Backer-Grøndahl  1 , Bjørnar H Moen, Sverre H Torp
Affiliations
Comparative Study

The histopathological spectrum of human meningiomas

Thomas Backer-Grøndahl et al. Int J Clin Exp Pathol. 2012.

Abstract

Histopathological examination and grading of meningiomas gives valuable prognostic information, although the method is subject for interobserver variability. The aim of this study was to review a large series of human meningiomas in order to examine the frequency of benign (grade I), atypical (grade II), and anaplastic (grade III) forms depending on various WHO classification schemes. In addition, we wanted to describe the frequency of various histopathological features and their mutual correlations. Sections from 196 consecutively treated primary human meningioma patients were revised retrospectively. The established criteria to grade meningiomas, which are also known to be associated with tumorigenesis, were shown to correlate significantly. The number of grade II meningiomas increased when using the WHO 2007 classification (30%) compared with previous editions, mainly due to the definition of brain infiltrating meningiomas as atypical (grade II). bimodal frequency distribution among age groups of females was observed. Continuous revision of histopathological classification systems is required to improve the diagnostic accuracy.

Keywords: Brain tumors; Clemmesen’s hook; classification; diagnosis; grading.

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Figures

Figure 1
Figure 1
Flow-diagram of patient inclusion.
Figure 2
Figure 2
Number of treated patients divided in age groups of five years, WHO grade, and gender. The age-grouped bars for females in Figure 2 A) indicate a bimodal curve.
Figure 3
Figure 3
Typical histological features encountered in human meningiomas: Mitoses (A), vesiculous nuclei with prominent nucleoli (B), small cell formation (C), brain infiltration (D), sheeting (E), and necroses (F).
See this image and copyright information in PMC

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