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Case Reports
. 2012;5(3):260-3.
Epub 2012 Mar 25.

One patient with double lymphomas: simultaneous gastric MALT lymphoma and ileal diffuse large B-cell lymphoma

Tadashi Terada  1
Affiliations
Case Reports

One patient with double lymphomas: simultaneous gastric MALT lymphoma and ileal diffuse large B-cell lymphoma

Tadashi Terada. Int J Clin Exp Pathol. 2012.

Abstract

Multiple different lymphomas in a single person are very rare. The author herein reports the case of a 69- year-old Japanese woman with double gastrointestinal lymphoma. The patient presented with epigastralgia. Endoscopic examination revealed erosions and elevation of the gastric body and a large ulcerated tumor of the terminal ileum. Biopsies were obtained from these lesions. The gastric lesion was MALT lymphoma with monocytoid B-cell proliferation and lymphoepithelial lesions. Light chain restriction was present. Helicobacter pylori were present on Giemsa stain. The gastric lesions did not regress despite of therapy, which were confirmed by follow-up biopsy. The ileal lesion was obvious diffuse large B-cell lymphoma. The lesion regressed by chemotherapy. The patient is now alive 3 years after the first presentation.

Keywords: Double lymphoma; gastric MALT lymphoma; ileal diffuse large B-cell lymphoma.

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Figures

Figure 1
Figure 1
Histology of the gastric lesion. A: Lymphoid proliferation is seen in a gastric biopsy. The lymphoid cells invade destructively the mucosal glands, muscularis mucosa, and submucosa. HE, x4; B: Higher power view shows that the lymphoid cells are small monocytoid cells. HE, x200; C: Lymphoepithelial lesions are seen. HE, x200; D: The lymphoid cells are positive for CD20, x200; E: The lymphoid cells are positive forκ-chain, x200; F: The lymphoid cells shows Ki-67 antiegn (labeling =5%), x100
Figure 2
Figure 2
A: Histology of the ileal lesion. It consists of diffuse proliferation of large lymphocytes. HE, x40; B: The lymphoid cells are large and show significant nuclear atypia. HE x200; The lymphoid cells are positive for CD20 (C), p53 (D) and Ki-67 antigen (Labeling=100%) (E).
See this image and copyright information in PMC

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