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Comment
. 2012 May 4;10(5):481-2.
doi: 10.1016/j.stem.2012.04.015.

Restoring cell polarity: an HSC fountain of youth

Carmen Carrillo-García  1 , Viktor Janzen
Affiliations
Free article
Comment

Restoring cell polarity: an HSC fountain of youth

Carmen Carrillo-García et al. Cell Stem Cell. .
Free article

Abstract

Until recently, aging was viewed as a fixed and irreversible process. However, in this issue of Cell Stem Cell, Florian et al. (2012) reveal a link between increased activity of the RhoGTPase Cdc42, hematopoietic stem cell polarity, and aging that can be regulated by pharmacological inhibition of Cdc42.

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  • Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
    Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H. Florian MC, et al. Cell Stem Cell. 2012 May 4;10(5):520-30. doi: 10.1016/j.stem.2012.04.007. Cell Stem Cell. 2012. PMID: 22560076 Free PMC article.

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