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. 2012 May 2;15(5):570-3.
doi: 10.1016/j.cmet.2012.03.004.

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

Robert V Farese Jr  1 , Rudolf Zechner, Christopher B Newgard, Tobias C Walther
Affiliations

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

Robert V Farese Jr et al. Cell Metab. .

Abstract

Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.

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