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Case Reports
. 2012 Sep;143(3):564-566.e1.
doi: 10.1053/j.gastro.2012.04.051. Epub 2012 May 3.

Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus

Mohammad Titi  1 , Andrew Overhiser  1 , Ozlem Ulusarac  1 , Gary W Falk  2 , Amitabh Chak  3 , Kenneth Wang  4 , Prateek Sharma  5
Affiliations
Case Reports

Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus

Mohammad Titi et al. Gastroenterology. 2012 Sep.

Abstract

Patients with Barrett's esophagus are frequently treated with radiofrequency ablation (RFA). Those that undergo this procedure have a low risk of developing subsquamous intestinal metaplasia, and none have been reported to develop subsquamous dysplasia or cancer. We report the development of subsquamous neoplasia in 3 patients who were treated with RFA for Barrett's esophagus (2 developed adenocarcinoma and 1 developed high-grade dysplasia). The identification of these cases indicates the need for continued surveillance following RFA, even after complete eradication of intestinal metaplasia, and caution for widespread use of ablation, especially in patients with low-risk Barrett's esophagus.

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Conflict of interest statement

Conflicts of interest

The authors disclose no conflicts.

Figures

Figure 1
Figure 1
(A) Alcian blue stain shows subsquamous intestinal metaplasia. (B) Subsquamous high-grade dysplasia (case 1).
Figure 2
Figure 2
(A) Low and (B) high power showing subsquamous adenocarcinoma (case 2).
See this image and copyright information in PMC

Comment in

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