Neonatal Kasabach-Merritt phenomenon
- PMID: 22563162
- PMCID: PMC3343255
- DOI: 10.4103/0971-5851.95150
Neonatal Kasabach-Merritt phenomenon
Abstract
Kasabach-Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy in the presence of a rapidly enlarging vascular tumor. It usually presents in early infancy, but onset in early neonatal period, facial hemangioma, and vincristine use in neonates has rarely been reported. We, hereby, present a 6-day-old male child presenting with facial hemangioma and intracranial hemorrhage, and KMP responding well to steroids and vincristine. Pathophysiology of disease and various treatment options have been discussed.
Keywords: Kasabach-Merritt phenomenon; neonate; vincristine.
Conflict of interest statement
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References
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- Kelly M. Kasabach-Merritt Phenomenon. Pediatr Clin North Am. 2010;57:1085–9. - PubMed
-
- Kasabach HH, Merritt KK. Capillary hemangioma with extensive purpura: Report of a case. Am J Dis Child. 1940;59:1063–70.
-
- Haisley-Royster C, Enjolras O, Frieden IJ, Garzon M, Lee M, Oranje A, et al. Kasabach-Merritt phenomenon: A retrospective study of treatment with vincristine. J Pediatr Hematol Oncol. 2002;24:459–62. - PubMed
-
- Shin HY, Ryu KH, Ahn HS. Stepwise multimodal approach in the treatment of Kasabach–Merritt syndrome. Pediatr Int. 2000;42:620–4. - PubMed
-
- Wananukul S, Nuchprayoon I, Seksarn P. Treatment of Kasabach–Merritt syndrome: A stepwise regimen of prednisolone, dipyridamole, and interferon. Int J Dermatol. 2003;42:741–8. - PubMed
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