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Comparative Study
. 2012 May;32(3):190-3.
doi: 10.3343/alm.2012.32.3.190. Epub 2012 Apr 18.

Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures

Jun-Hwa Lee  1 , Jeong Hyun Kim
Affiliations
Comparative Study

Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures

Jun-Hwa Lee et al. Ann Lab Med. 2012 May.

Abstract

Background: Changes in levels of trace elements have been proposed to underlie febrile seizures. Particularly, low zinc levels have been proposed as related factor of febrile seizure. In this study, we investigated whether mean serum zinc levels differed between children with febrile seizure and afebrile seizure.

Methods: Using inductively coupled plasma mass spectrometry, serum zinc levels were measured in 288 children who had been diagnosed with febrile seizures (N=248) and afebrile seizures (N=40). Mean serum zinc levels were compared between the 2 groups.

Results: Mean serum zinc level was 60.5±12.7 µg/dL in the febrile seizure group and 68.9 ±14.5 µg/dL in the afebrile seizure group. A significant difference in serum zinc levels was observed between the febrile and afebrile seizure groups (P<0.001).

Conclusions: Zinc levels in children with febrile seizure were significantly lower than those in children with afebrile seizure.

Keywords: Febrile seizure; Mass spectrometry; Zinc.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Comparison of serum zinc levels in children with febrile seizures and afebrile seizures. Mean serum zinc levels in the febrile seizure and afebrile seizure groups were 60.5±12.7 µg/dL and 68.9±14.5 µg/dL, respectively. Mean serum zinc levels were significantly different between these groups, according to an independent t-test (P<0.001).
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References

    1. Martindale JL, Goldstein JN, Pallin DJ. Emergency department seizure epidemiology. Emerg Med Clin North Am. 2011;29:15–27. - PubMed
    1. Siqueira LF. Febrile seizures: update on diagnosis and management. Rev Assoc Med Bras. 2010;56:489–492. - PubMed
    1. Liscák R, Vladyka V, Simonová G, Vymazal J, Novotny J., Jr Gamma knife surgery of brain cavernous hemangiomas. J Neurosurg. 2005;102(Suppl):207–213. - PubMed
    1. Guerreiro MM. Treatment of febrile seizures. J Pediatr (Rio J) 2002;78(Suppl 1):S9–S13. - PubMed
    1. Consensus statement. Febrile seizures: long-term management of children with fever-associated seizures. Pediatrics. 1980;66:1009–1012. - PubMed

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