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. 2011 Aug 15;4(3):275-9.
Epub 2011 Aug 25.

Highlights in the minimally invasive treatment of SUI in women

C Surcel  1 , C Chibelean, A Iordache, C Mirvald, C Gîngu, S Margaritis, R Stoica, C Codoiu, C Savu, R Marksteiner, I Sinescu
Affiliations

Highlights in the minimally invasive treatment of SUI in women

C Surcel et al. J Med Life. .

Retraction in

  • Retractions.
    [No authors listed] [No authors listed] J Med Life. 2012 Jun 12;5(2):246-7. Epub 2012 Jun 18. J Med Life. 2012. PMID: 22802902 Free PMC article. No abstract available.

Abstract

Objective: Treatment of stress urinary incontinence consists of a wide range of options, from conservative therapies like lifestyle changes, medication, pelvic floor muscles exercises, electro-stimulation, to minimally invasive procedures--injection of collagen, suburethral slings TVT/TOT and last but not least, invasive surgical treatment reserved for recurrent and complex cases. Among the latest minimally invasive procedures reported in literature, the injection of intra-and perisphincterian of autologous stem cell (mioblasts and/or mature fibroblasts grown and multiplied in the laboratory from biopsy samples taken from the pectoralis muscles).

Material and method: On October 18, 2010, in 'Fundeni' Clinical Institute of Uronephrology and Renal Transplantation was performed the first stem cell implantation procedure in the urethral sphincter, in Romania.

Results: Assessment at 6 weeks, the quality of life questionnaires, micturition diary and clinical examination revealed a stunning decrease of urine loss from 6 pads/day at one per day, which significantly improved the patient's quality of life.

Conclusions: Stem-cell-mioblasts therapy may represent in the future an every-day intervention in the urologist's armamentarium. The effectiveness of this treatment can change the course of therapy and last but not least, the accessibility to urological evaluation of patients with stress urinary incontinence. Clinical and urodynamic evaluations will continue and will be future scientific topics.

Keywords: minimal invasive treatment; stem cells; stress urinary incontinence; urethral sphincter.

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Figures

Figure 1
Figure 1
Theoretical scheme of stem cells implantation (With the permission of Prof. Marksteiner)
Figure 2
Figure 2
Mioblast growth in cell culture –200x, antiDesmine staining
Figure 3
Figure 3
Mioblasts fusion to the miotubuli in cell culture –200x, antiDesmnine staining (with the permission of Prof. Marksteiner).
Figure 4
Figure 4
Urethral sphincter ultrasound – intraoperative aspect
See this image and copyright information in PMC

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