Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:712736.
doi: 10.1155/2011/712736. Epub 2011 Apr 10.

BCG Vaccination in HIV-Infected Children

James J C Nuttall  1 , Brian S Eley
Affiliations

BCG Vaccination in HIV-Infected Children

James J C Nuttall et al. Tuberc Res Treat. 2011.

Abstract

Despite the use of Bacillus Calmette-Guérin (BCG) vaccination for many years, infants and young children exposed to adults with infectious forms of tuberculosis (TB) are at high risk of developing complicated TB disease. This risk is much higher among HIV-infected children, and data on BCG protective efficacy in HIV-infected children is lacking. Recent research on BCG safety in HIV-infected infants has resulted in policy shifts, but implementation is challenging. New approaches to preventing TB among infants and children, particularly HIV-infected infants, are needed. This paper briefly reviews BCG safety and efficacy considerations in HIV-infected infants and discusses other approaches to preventing TB, including new TB vaccines and vaccination strategies.

PubMed Disclaimer

References

    1. Fine PEM, Carneiro IAM, Milstien JB, Clements C. Issues relating to the use of BCG in immunization programmes: a discussion document (WHO/V&B/99.23) Geneva, Switzerland: World Health Organization; 1999.
    1. Hesseling AC, Cotton MF, Jennings T, et al. High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies. Clinical Infectious Diseases. 2009;48(1):108–114. - PubMed
    1. Hesseling AC, Behr MA. BCG: history, evolution, efficacy, and implications in the HIV era. In: Schaaf HS, Zumla AI, editors. Tuberculosis: A Comprehensive Clinical Reference. India: Saunders Elsevier; 2009. pp. 759–770.
    1. Fine PEM, Sterne JAC, Ponnighaus JM, Rees RJW. Delayed-type hypersensitivity, mycobacterial vaccines and protective immunity. Lancet. 1994;344(8932):1245–1249. - PubMed
    1. Soares AP, Scriba TJ, Joseph S, et al. Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. Journal of Immunology. 2008;180(5):3569–3577. - PMC - PubMed

LinkOut - more resources