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Clinical Trial
. 1990 Nov;49(11):926-8.
doi: 10.1136/ard.49.11.926.

5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study

J A Casas  1 , P A Saway, I Villarreal, C Nolte, B L Menajovsky, E E Escudero, W D Blackburn, G S Alarcón, C P Subauste
Affiliations
Clinical Trial

5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study

J A Casas et al. Ann Rheum Dis. 1990 Nov.

Abstract

A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually responded to dose reduction. Two patients receiving 5-fluorouracil died from causes seemingly unrelated to treatment. Significant clinical improvement in scleroderma was not noted in the first six months of treatment with 5-fluorouracil.

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