Sialadenoma papilliferum: clinical misdiagnosis with a histological decree

Abstract

Sialadenoma papilliferum is a rare salivary gland tumor clinically resembling papilloma originating probably from the excretory duct. It is characterized by a biphasic growth pattern of exophytic squamous component and endophytic glandular component. We report a rare case of sialadenoma papilliferum in the floor of the mouth with epithelial dysplasia with pertinent review of literature. The present case highlights the importance of keeping sialadenoma papilliferum as a differential diagnosis of exophytic papilliferous oral lesions and the need to explore the etiology and malignant potential of the tumor.

Figure 1

Surface papillary projections lined by a parakeratotic, acanthotic stratified squamous epithelium at 40x.

Figure 2

Dysplastic features such as basal cell hyperplasia, nuclear and cellular pleomorphism, and nuclear hyperchromatism at 400x.

Figure 3

Mitotic figures under oil immersion 1000x.

Figure 4

Mucous salivary gland with extralobular dilated tortuous ducts at 40x.

Figure 5

Dilated tortuous ducts lined by luminal columnar cells and abluminal cuboidal cells at 400x.