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Case Reports
. 2011:2011:356370.
doi: 10.1155/2011/356370. Epub 2011 Jun 30.

Vancomycin-associated leukocytoclastic vasculitis

Makhawadee Pongruangporn  1 , David J Ritchie, Dongsi Lu, Jonas Marschall
Affiliations
Case Reports

Vancomycin-associated leukocytoclastic vasculitis

Makhawadee Pongruangporn et al. Case Rep Infect Dis. 2011.

Abstract

Vancomycin is U.S. Food and Drug Administration (FDA) approved for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or in individuals who have failed, cannot tolerate, or are allergic to other antibiotics. Very few cases of vancomycin-associated leukocytoclastic vasculitis have been published. We report on a patient who developed pruritus and palpable purpura in both lower extremities after receiving six days of intravenous vancomycin. Skin biopsy revealed leukocytoclastic vasculitis.

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Figures

Figure 1
Figure 1
On day 6 after starting vancomycin, the patient develops a pruritic, nonblanching erythematous rash on both legs, buttocks and lower back area.
Figure 2
Figure 2
High power view (400x) shows perivascular neutrophilic infiltrate with fibrinoid necrosis of vessel wall, abundant nuclear dust and red blood cell extravasation.
See this image and copyright information in PMC

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